The original Townsend Hall was located at 25 Niagara Square (where the City Court Building stands today) in the City of Buffalo. The building was donated to the University's infant College of Arts and Sciences program by the Women's Educational and Industrial Union of Buffalo in 1915, provided that the University raised $100,000 towards a future endowment. On February 22, 1916, Grace Millard Knox donated $250,000 in memory of her late husband, Seymour H. Knox. This was more than enough to assure the future of the growing institution.
The conditions of the gift also required that the building be named "Townsend Hall" and that "if said premises be sold by the University of Buffalo, this name shall be perpetuated by the University." In 1922 the College of Arts and Sciences moved to Foster Hall on the University's new campus on Main Street and Townsend Hall on Niagara Square became the home of UB's Millard Fillmore College and the School of Social Work.
In 1954, after the building on Niagara Square was vacated by the University, the Townsend name was transferred to the Biology Building on the Main Street Campus.
Townsend Hall was named for Harriet A. Townsend (1839-1916) who founded the Women's Educational and Industrial Union of Buffalo in 1884. The organization was dedicated to promoting "the material, moral and intellectual welfare of the women of our city," and did so with lectures, classes and vocational training at the original Townsend Hall on Niagara Square in downtown Buffalo.