The building at 2211 Main Street in the City of Buffalo was constructed circa 1908 and first served as the U.S. Marine Hospital. UB purchased the building and three others on the site in 1950. The site was the home of UB's Chronic Disease Research Institute and later UB's Western New York Technology Development Center. In 1994, the site was sold to the Sisters of Charity Hospital who intended to tear the buildings down to expand off-street parking. However, due to its landmark status, the original Marine Hospital building was spared. In 1997, the building opened as Benedict House, offering residence and support services for people living with AIDS. In 2018, the building was purchased by Cazenovia Recovery Systems for use as residences and support services for people recovering from substance abuse addictions.